1.Date of occurrence of the change:2018/11/14
2.Appointment of or changed personnel (juristic-person director,
  juristic-person supervisor, independent director, natural-person
  director or natural-person supervisor):
juristic-person director、Independent Director、natural-person director
3.Title, name and resume of the replaced personnel:
(1) Wang, Hsun-Sheng， The company Chairman
(2) Wang, Hsun-Hui， The company Director
(3) Mr.Wang Ming-Ning Foundation Representative:
Tsai, Ching-Chung， The company Director
(4) Cheng, Hsi-I， The company Director
(5) Chen, Hung-Shou，The company Independent Director
(6) Wu, Su-Huan，The company Independent Director
(7) Pei, Min-Li，The company Independent Director
4.Title, name and resume of the new personnel:
(1) representative of Chunghwa Chemical Synthesis & Biotech Co. Ltd.：
Wang, Hsun-Sheng， The company Chairman
(2) Mr.Wang Ming-Ning Foundation Representative: Wang, Hsun-Huig，
The company Director
(3) Chen, Hung-Shou，The company Independent director
(4) Wu, Su-Huan，The company Independent director
(5) Zhou,Yan-Peng， Chairman of  InQuartik Co. Ltd.
5.Type of the change (please enter: “resignation”, “discharge”, “tenure
  expired”, “death” or “new appointment” ):Term expires
6.Reason for the change:Reelection
7.Number of shares held by the new personnel at the time of
  appointment:
(1) Chunghwa Chemical Synthesis & Biotech Co. Ltd. :
Wang, Hsun-Sheng：13,747,137 share
(2) Mr.Wang Ming-Ning Foundation Representative:
Wang, Hsun-Huig：10,432,912 share
(3) Chen, Hung-Shou：0 share
(4) Wu, Su-Huan：0 share
(5) Zhou,Yan-Peng：0 share
8.Original term (from __________ to __________):2016/05/27-2019/05/26
9.Effective date of the new appointment:2018/11/14
10.Rate of turnover of directors of the same term:N/A
11.Rate of turnover of supervisor of the same term:N/A
12.Rate of turnover of independent director of the same term:N/A
13.Change in one-third or more of directors (“Yes” or “No”):YES
14.Any other matters that need to be specified:None